Pycnogenol is an amazing combination of over 40 antioxidants and is one of the most powerful compounds yet discovered, scavenging free radicals before they can damage skin structure and enhancing the antioxidant activity of both vitamin E and vitamin C. Pycnogenol is a trademarked name for pine bark extract which doctors have used to treat a variety of conditions for over two thousand years. Hippocrates, the founder of modern medicine, used pine bark as a remedy for inflammatory diseases in the 4th century B.C.